J. Peter Wells, an expose writer, arrives on an island off the coast of South America (no country identified), to complete a book on voodoo, ju-ju,macumba, mojo and other cult beliefs, which he believes is responsible for unsolved murders on this island. Wealthy land-owner Venis de Vias warns him against stirring up the natives, especially any efforts to lessen the prestige of the reigning VooDoo Queen Mama Rata-loi. The arrival of Wells' daughter, Sara, and her husband, Warren, on a honeymoon trip, starts the pot to boiling and making the natives restless. Most restless of all is Mama Rata-loi, who asserts her powers and puts a spell on Venus de Viasa. The next thing honeymooner Warren knows is that he is trussed up and about to become the one chosen to die in a voodoo ceremony.